Richard A. Mazzarella, Ph.D.
Pfizer Inc.
Global Research and Development
Computational Biology
4320 Forest Park Avenue, Suite 302
St. Louis, MO 63108
office - 314-615-6628
WORK EXPERIENCE
EDUCATION AND SKILLS
PUBLICATIONS
PATENT
Bauer, Christopher Todd (St. Louis, MO, US) Bourner, Maureen Jeri (Defiance, MO, US) Boyle, Melanie (Granta Park, GB) Casperson, Gerald Fries (Ballwin, MO, US) Griggs, David William (Ballwin, MO, US) Head, Richard David (O'Fallon, MO, US) Joy, William Dean (St. Louis, MO, US) Mazzarella, Richard Allen (Webster Groves, MO, US) Minter, Ralph Raymond (Cambridge, GB) Moffat, Mark Allen (St. Louis, MO, US) Thiele, Barrett Richard (St. Louis, MO, US) Vanarsdale, Todd Lee (Carlsbad, CA, US) P-Cadherin Antibodies US Patent 7452537 (November 18, 2008).
BOOK
Mazzarella, R. and Head, R., eds. Computational and Systems Biology: Methods and Applications. (2009). Research Signpost, Trivandrum.
BOOK CHAPTERS
1. Green, M. and Mazzarella, R.A. (1988). Proteins, biosynthesis. In
"Encyclopedia of
Polymer Science and Engineering" (Mark, Bikales, Overberger and Menges,
eds.) Vol. 13, pp. 628-650. John Wiley and Sons, Inc., New York. 
2. Green, M. and Mazzarella, R.A. (1988). Biosynthesis and sorting of proteins of the
endoplasmic reticulum. In "Protein Transfer and Organelle Biogenesis" (Das
and Robbins, eds.) pp. 243-288. Academic Press, New York.
3. Head R., Barve, R. and Mazzarella, R.
(2009). Microarrays in research: A decade of application in industry. In "Computational and
Systems Biology: Methods and Applications". (Mazzarella and Head, eds.)
pp. 13-49. Research Signpost, Trivandrum.
4. Mazzarella, R. and Webb, C. (2011). Computational and bioinformatic strategies in indications discovery research. In "Drug Repositioning: Bringing New Life to Shelved Assets" (Barratt and Frail, eds.) in preparation. John Wiley & Sons, New York.
ARTICLES
1.
Gold, P., Lewis, M., Mazzarella, R. and Green, M. (1985). An enzyme-linked immunoassay for
antibodies to endoplasmic reticulum. Anal. Biochem. 146, 82-89.
2.
Lewis, M.J., Mazzarella, R.A. and Green, M. (1985). Structure and assembly of the
endoplasmic reticulum: The synthesis of three major endoplasmic reticulum proteins during
lipopolysaccharide-induced differentiation of murine lymphocytes. J. Biol. Chem.
260, 3050-3057.
3.
Lewis, M.J., Mazzarella, R.A. and Green, M. (1986). Structure and assembly of the
endoplasmic reticulum: biosynthesis and intracellular sorting of ERp61, ERp59 and
ERp49, three proteins of murine endoplasmic reticulum. Arch. Biochem. Biophys.
245, 389-403.
4.
Mazzarella, R.A. and Green, M. (1987). ERp99, an abundant, conserved glycoprotein of the
endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the
94-kDa glucose regulated protein (GRP94). J. Biol. Chem. 262, 8875-8883.
5.
Mazzarella, R.A., Srinivasan, M., Haugejorden, S.M. and Green, M. (1990). ERp72, an
abundant luminal endoplasmic reticulum protein, contains three copies of the active site
sequences of protein disulfide isomerase. J. Biol. Chem. 265, 1094-1101.
6.
Mazzarella, R., Montanaro, V., Kere, J., Reinbold, R., Ciccodicola, A., D'Urso, M. and
Schlessinger, D. (1992). Conserved sequence-tagged sites (STSs): a phylogenetic
approach to genome mapping. Communicated by James D. Watson.
Proc. Natl. Acad. Sci. USA 89, 3681-3685.
7.
Mazzarella, R.A., Gold, P., Cunningham, M. and Green, M. (1992). Determination of the
sequence of an expressible cDNA clone encoding ERp60/calregulin by the use of a
novel nested set method. Gene 120, 217-225.
8.
Mazzarella, R.A., Marcus, N., Haugejorden, S.M., Balcarek, J.M., Baldassare, J.J., Roy,
B., Li, L.- J., Lee, A.S., and Green, M. (1994). ERp61 is GRP58, a stress-inducible
luminal endoplasmic reticulum protein, but is devoid of phosphoinositide-specific
phospholipase C activity. Arch. Biochem. Biophys. 308, 454-460.
9.
Qu, D., Mazzarella, R.A. and Green, M. (1994). Analysis of the structure and
synthesis of GRP94, an abundant stress protein of the endoplasmic reticulum. DNA and Cell
Biol. 13, 117-124.
10.
Mazzarella, R. and Srivastava, A.K. (1994). Physical linkage of expressed sequence tags
(ESTs) to polymorphic markers on the X chromosome. Hum. Mol. Genet. 3, 1095-1101.
11.
D'Esposito, M., Mazzarella, R., Pengue, G., Jones, C., D'Urso, M. and
Schlessinger, D. (1994). PCR-based immortalization and screening of hierarchical
pools of cDNAs. Nucl. Acids Res., 22, 4806- 4809.
12.
Zollo, M., Mazzarella, R., Bione, S., Toniolo, D., Schlessinger, D., D'Urso, M. and Chen
E.Y. (1995). Sequence and gene content of the RCP/GCP-G6PD region in human Xq28: the first
52 kb. DNA Seq. 6, 1-11.
13.
De Maria, A.C., Gomes, S.L., Juliana, M.H., Mazzarella, R. and Klein, C. (1995). Cloning
of a cDNA encoding a novel heat shock protein from Dictyostelium discoideum. Gene 163,
163-164.
14.
Mazzarella, R., Ciccodicola, A., Esposito, T., Arcucci, A., Migliaccio, C., Jones., C.,
Schlessinger, D., D' Urso, M. and D' Esposito, M. (1995). Human protein kinase C
iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. Genomics 26, 629-631.
15.
Chen, E.Y., Zollo, M., Mazzarella, R., Ciccodicola, Chen, C-N., A., Zuo, L., Heiner, C.,
Burough, F., Ripetto, M., Schlessinger, D. and D'Urso, M. (1996). Long-range
sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of
high GC DNA between the RCP/GCP and G6PD. Hum. Mol. Genet. 5, 659-668.
16.
D'Esposito, M., Ciccodicola, A., Gianfrancesco, F., Esposito, T., Flagiello L., Mazzarella
R., Schlessinger, D. and D'Urso, M. (1996). A synaptobrevin-like gene in the Xq28
pseudoautosomal region undergoes X inactivation. Nature Genet. 13, 227-229.
17.
Chen, C.-N. , Su, Y., Baybayan, P., Siruno, A., Nagaraja, R., Mazzarella, R., Schlessinger
D. and Chen, E. (1996). Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2
and four possible genes, including three confirmed by EST matches. Nucl. Acids
Res. 24, 4034-4041.
18.
Esposito, T., Ciccodicola, A., Flagiello, L., Matarazzo, M.R., Migliaccio, C., Cifarelli,
R.A., Visione, R., Campanile, C., Mazzarella, R., Schlessinger, D., D'Urso, M. and
D'Esposito, M. (1997). Expressed STSs and transcription of human Xq28. Gene 187, 185-191.
19.
Nagaraja, R., MacMillan, S., Kere, J., Jones, C., Griffin, S., Schmatz, M., Terell, J.,
Shomaker, M., Jermak, C., Hott, C., Masisi, M., Mumm, S., Srivastava, A., Pilia, G.,
Featherstone, T., Mazzarella, R., Kesterson, S., McCauley, B., Railey, B., Burough,
F., Nowotny, V., D'Urso, M., States, D., Brownstein, B. and Schlessinger, D. (1997).
X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC
content. Genome Res. 7, 210-222.
20.
Mazzarella, R., Pengue, G., Yoon, J., Jones, J. and Schlessinger, D. (1997). Differential
expression of XAP-5, a candidate disease gene. Genomics 45, 216-219.
21.
D'Esposito, M., Matarazzo, M., Ciccodicola, A., Strazzullo, M., Mazzarella,
R., Quaderi,
N.A., Fujiwara, H., Ko, M.S.H., Rowe, L.B., Ricco, A., Archidiacono, N., Rocchi, M.,
Schlessinger, D. and D'Urso, M. (1997). Differential expression pattern of
XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the
region. Hum. Mol. Genet. 6, 1917-1923.
22.
Grieff, M., Whyte, M.P., Thakker, R.V. and Mazzarella, R. (1997). Sequence analysis of 139
kb containing spermine synthase and the 5' region of PEX in Xp22.1. Genomics, 44, 227-231.
23.
Grieff, M., Mumm, S., Waeltz, P., Mazzarella, R., Whyte, M.P., Thakker, R.V., and
Schlessinger, D. (1997). Expression and cloning of the human X-linked
hypophosphatemia gene (PEX) cDNA. Biochem. Biophys. Res. Comm. 231, 635-639.
24.
Mazzarella, R. and Schlessinger, D. (1997). Duplication and distribution of repetitive
elements and non-unique repeats in the human genome. Gene, 205, 29-38.
25.
Huber, R., Crisponi, L., Mazzarella, R., Chen, C.-N., Su, Y., Shizua, H., Chen, E. Y.,
Cao, A., and Pilia, G. (1997). Analysis of exon/intron structure and 400 kb of
genomic sequence surrounding the 5'- promoter and 3'-terminal ends of the human glypican 3
(GPC3) gene. Genomics 45, 48-58.
26.
Esposito, T., Gianfrancesco, F., Ciccodicola, A., D'Esposito, M., Nagaraja, R.,
Mazzarella, R., D'Urso, M. and Forabosco, A. (1997). Escape from X-inactivation of
two new genes associated with DXS6974E and DXS7020E. Genomics 43, 183-190.
27. Rouchka, E.C., Mazzarella, R. and States, D.J. (1997). Computational
detection of CpG islands in DNA. WUCS Tech. Rep. 97(39), 1-18.
28.
Mazzarella, R. and Pilia, G. (1998). Recombination trapping: an "in vivo"
approach to recover cDNAs encoded in YACs. Gene 212, 315-322.
29.
Gianfrancesco, F., Esposito, T., Montanini, L., Ciccodicola, A., Mumm, S., Mazzarella,
R.,
Rao, E., Giglio, S., Rappold G. and Forabosco, A. (1998). A novel Xp/Yp pseudoautosomal
gene encoding a putative GTP-binding protein. Hum. Mol. Genet. 7, 407-414.
30. Mazzarella, R., Pengue, G., Jones, J., Jones, C. and Schlessinger, D. (1998). Cloning and
expression of an immunoglobulin superfamily gene (IGSF1) in Xq25. Genomics 48, 157-162.
31.
Mazzarella, R. and Schlessinger, D. (1998). Pathological consequences of sequence
duplications in the human genome. Genome Res. 8, 1007-1021.
32.
Huber, R., Mazzarella, R., Chen, C.-N., Chen, E., Ireland, M., Lindsay, S., Pilia, G. and
Crisponi, L. (1998). Glypican 3 and glypican 4 are juxtaposed in Xq26.1. Gene 225, 9-16.
33.
Huber, R., Hansen, S., Strazzullo, M., Pengue, G., Mazzarella, R., D'Urso, M.,
Schlessinger, D., Pilia, G., Gartler, S.M., and D'Esposito M. (1999). DNA methylation in
transcriptional repression of two differentially expressed X-linked genes, GPC3 and SYBL1.
Proc. Natl. Acad. Sci. USA 96, 616-621.
34.
Gianfrancesco, F., Esposito, T., Ciccodicola, A., D'Esposito, M., Mazzarella,
R., D'Urso,
M. and Forabosco, A. (1999). Molecular cloning and fine mapping of API5L1, a novel human
gene strongly related to an antiapoptotic gene. Cytogenet. Cell Genet. 84, 164-166.
35.
Nakashima, H., Grahovac, M.J., Mazzarella, R., Fujiwara, H., Kitchen, J.R., Threat. T.A.
and Ko, M.S.H. (1999). Two novel mouse genes - Nubp2, mapped to the t-complex on
chromosome 17, and Nubpl, mapped to chromosome 16 - establish a new gene family of
nucleotide binding proteins in eukaryotes. Genomics 60, 152-160.
36. Weinstein, E.J., Bourner, M., Head, R., Zakeri, H., Bauer, C. and
Mazzarella, R. (2003). URP1: A member of a novel family of PH and FERM
domain-containing membrane-associated proteins is significantly over-expressed
in lung and colon carcinomas. Biochim. Biophys. Acta 1637, 207-216.
37. Weinstein, E.J., Head, R., Griggs, D.W., Sun, D., Evans, R.J.,
Swearingen, M.L., Westlin, M.M. and Mazzarella, R. (2006). VCC-1, a novel
chemokine, promotes tumor growth. Biochem. Biophys. Res. Comm. 350, 74-81.
38. Hills, R., Mazzarella, R., Fok, K., Liu, M., Nemirovsky, O.,
Leone, J., Zack, M.D., Arner, E.C., Viswanathan, M., Abujoub, A., Muruganandam,
A., Sexton, D.J., Bassill, G.J., Sato, A.K., Malfait, A.M. and Tortorella, M.D.
(2007). Identification of an ADAMTS-4 cleavage motif using phage display leads
to the development of fluorogenic peptide substrates and reveals matrilin-3 as a
novel substrate. J. Biol. Chem. 282, 11101-11109.
39. Bolten, C.W., Blanner, P.M., McDonald, W.G., Staten, N.R., Mazzarella,
R.A., Arhancet, G.B., Meier, M.F., Weiss, D.J., Sullivan, P.M., Hromockyj,
A.E., Kletzien, R.F. and Colca, J.R. (2007). Insulin sensitizing pharmacology of
thiazolidinediones correlates with mitochondrial gene expression rather than
activation of PPARg.
Gene Reg. Systems Biol. 1, 73-82.
40. Hyde, C.L., MacInnes, A.,
Sanders, F.A., Thompson, J.F., Mazzarella,
R.A.,
Faergeman, O., van Wijk, D.,
Wood, L., Lira, M,
and Paciga, S.A. (2010). Genetic association of the CCR5 region with
lipid levels in at-risk cardiovascular patients. Circ. Cardiovasc. Genet. 3,
162-168.
41. Mazzarella, R., Roberds, S.L., Krul, E.S., Chang, M., Hyde, C.L., Hinds, D.A., Frazer, K.A., Milos, P.M. and Thompson, J.F. (2011). Identification of loci in the human genome which are associated with multiple metabolic syndrome phenotypes. in preparation.
SCIENTIFIC COMMUNITY CONTRIBUTIONS
>1000 Scientific Journal References
>3300 DNA Sequence References in GenBank
>130 Protein Sequence References in GenBank
16 Human Genes References in OMIM
